Creative mistakes stimulate the brain
This study of Shakespeare's linguistic innovations — neologisms, unorthodox syntax, etc. — and the brain is exciting stuff and has, AFAIC, everything to do with compositional innovation and experiment in music. As with Shakespeare, I strongly suspect that every major innovator in music has done things with sounds or their context that make the brain work more than usual and it is precisely that stimulation that keeps this music worth returning to again and again.
I also think that many of the methods, often game-like, of the Oulipo in literature, the surrealists in literature and the visual arts, and many composers, particularly experimentalists, are designed as efficient means for getting right into that more-stimulated zone, often enstranging the familiar through even the slightest shifts in the selection or character of materials or their order in time or space.
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